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Iran J War Public Health 2021, 13(3): 185-188 Back to browse issues page
Eosinopenia; a Predictor of Non-Respiratory COVID-19
T. Kadhim 1, H. Abdulilah2
1- Department of Internal Medicine, College of Medicine, University of Basrah, Basrah, Iraq , talibkadum @gmail.com
2- Department of Internal Medicine, College of Medicine, University of Basrah, Basrah, Iraq
Abstract:   (682 Views)

Aims: Eosinopenia is a form of agranulocytosis where the number of eosinophil granulocytes is lower than expected, which is observed in many viral and bacterial infections. This study aimed to investigate eosinopenia in non-respiratory COVID-19 patients.
Materials & Methods: This experimental study was conducted on COVID-19 patients who had the positive PCR test in an outpatient clinic in Al-Feiha Teaching Hospital in Basrah, Iraq. One hundred four patients were selected from June to November 2020. Full blood counts and estimation of the inflammatory marker C-reactive protein were done. The Chi-square statistical test in SPSS 20 software was used for data analysis.
Findings: Eosinopenia observed in 47 patients (45.1%); 20 patients (19%) were respiratory COVID-19 and 27 patients (26%) were non-respiratory COVID-19. Total white blood cell count reduced in 17 patients & increased in 30 patients while normal in 57 patients. Logistic regression analysis indicated that eosinopenia is a significant independent predictor of non-respiratory COVID-19 infection (p=0.008; B=0.0001).
Conclusion: Eosinopenia is a predictor of COVID-19 infection in patients with non-respiratory illnesses.
 

Keywords: Eosinopenia [MeSH], Non-Respiratory [MeSH], COVID-19 [MeSH],
Full-Text [PDF 368 kb]   (46 Downloads)    
Article Type: Analytic Review | Subject: Veterans or Handicapped Health
Received: 2021/08/22 | Accepted: 2021/08/25 | Published: 2021/11/8
References
1. Huanng I, Pranta R. Lymphopenia in sever coronavirus disease - 19 (COVID-19): Systematic review and meta-analysis. J Intensive Care. 2020;8:36. [Link] [DOI:10.1186/s40560-020-00453-4] [PMID] [PMCID]
2. Cucinotta D, Vanelli M. WHO declares COVID-19 a pandemic. Acta Biomed. 2020;91(1):157-60. [Link]
3. De Oliveira Toledo SL, Nogueira LS, Cavalho MDG, Rios DRA, De Barros Penheiro M. COVID-19: Review and hematological impact. Clin Chim Acta. 2020;510:170-6. [Link] [DOI:10.1016/j.cca.2020.07.016] [PMID] [PMCID]
4. Woolf SH, Masters R, Aron L. Effect of COVID-19 pandemic in 2020, on life expectancy across populations in the USA and other high income countries: Simulations of provisional mortality data. BMJ. 2021;373:1343. [Link] [DOI:10.1136/bmj.n1343] [PMID] [PMCID]
5. Ni W, Yang X, Yang D, Bao J, Li R, Xiao Y, et al. Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19. Crit Care. 2020;24(1):422. [Link] [DOI:10.1186/s13054-020-03120-0] [PMID] [PMCID]
6. Geblawi M, Wang K, Viveiros A, Nguyen Q, Zhang JC, Turnur AJ, et al. Angiotensin-converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system: Celebrating the 20th anniversary of the discovery of ACE2. Circ Res. 2020;126(10):1456-74. [Link] [DOI:10.1161/CIRCRESAHA.120.317015] [PMID] [PMCID]
7. Terpos E, Ntanasis-Stathopoulos I, Elalamy I, Kastritis E, Sergentanis TN, Politou M, et al. Hematological finding and complications of COVID-19. Am J Hematol. 2020;95(7):834-47. [Link] [DOI:10.1002/ajh.25829] [PMID] [PMCID]
8. Tan L, Wang Q, Zang D, Ding J, Huang Q, Tang YQ, et al. lymphopenia predicts disease severity of COVID-19: A descriptive and predictive study. Signal Transduct Target Ther. 2020;5(1):3. [Link] [DOI:10.1038/s41392-020-0159-1] [PMID] [PMCID]
9. Tang Y, Liu J, Zhang D, Xu Z, Ji J, Wen C. Cytokin storm in COVID-19: The current evidence and treatment strategies. Front Immunol. 2020;11:1708. [Link] [DOI:10.3389/fimmu.2020.01708] [PMID] [PMCID]
10. Rachel N. Eosinopphil, eosinophilia, and other disorders [Internet]. Brighton: Medical News Today; 2017 [cited: unknown]. Available from: https://www.medicalnewstoday.com/articles/311601. [Link]
11. Park YM, Bochner BS. Eosinophil survival and apoptosis in health and disease. Allergy Asthma Immunol Res. 2010;2(2):87-101. [Link] [DOI:10.4168/aair.2010.2.2.87] [PMID] [PMCID]
12. Rosenberg H, Phipps S, Foster P. Eosinophil trafficking in allergy and asthma. J Allergy Clin Immunol. 2007;119(6):1303-10. [Link] [DOI:10.1016/j.jaci.2007.03.048] [PMID]
13. Sur S, Adolphson C, Gleich G. Eosinophils: Biochemical and cellular aspects. Saint Louis: Mosby; 1993. [Link]
14. Celli B. Is the blood eosinophil count a useful biomarker in copd? the devil is in the details!. Arch Bronconeumol. 2017;53(8):415-6. [Spanish] [Link] [DOI:10.1016/j.arbres.2017.01.011] [PMID]
15. Long H, Liao W, Wang L, Lu Q. A player and coordinated: The versatile roles of eosinophils in immune system. Transfuse Med Hemother. 2016;43(2):96-108. [Link] [DOI:10.1159/000445215] [PMID] [PMCID]
16. Marnell L, Mold C, Du Clos TW. C-reactive protein: Ligands, receptors and role in inflammation. Clin Immunol. 2005;117(2):104-11. [Link] [DOI:10.1016/j.clim.2005.08.004] [PMID]
17. Fraisse M, Lgre E, Mentec H, Cally R, Plantefve G, Contou D. Eosinophilia in critically ill COVID-19 patients: A French monocentric retrospective study. Crit Care. 2020;24(1):635. [Link] [DOI:10.1186/s13054-020-03361-z] [PMID] [PMCID]
18. Tanni F, Akker E, Zaman MM, Figueroa N, Tharian B, Hupart KH. Eosinopenia and COVID-19. J Am Osteopath Assoc. 2020 Jul:7556. [Link] [DOI:10.7556/jaoa.2020.091] [PMID]
19. Huang J, Zhang Z, Liu S, Gong C, Chen L, Ai G, et al. Absolute eosinophil count predicts intensive care unit transfer among elderly COVID-19 patients from general isolation wards. Front Med. 2020;7:585222. [Link] [DOI:10.3389/fmed.2020.585222] [PMID] [PMCID]
20. Yan B, Yang J, Xie Y, Tang X. Relationship between a blood eosinophil level and COVID-19 mortality. World Allergy Organ J. 2021;14(3):100521. [Link] [DOI:10.1016/j.waojou.2021.100521] [PMID] [PMCID]
21. Xie G, Ding F, Han L, Yin D, Lu H, Zang M. The role of peripheral blood eosinophil counts in COVID-19 patients. Allergy. 2021;76(2):471-82. [Link] [DOI:10.1111/all.14465] [PMID] [PMCID]
22. Outh R, Boutin C, Gueudet P, Suzuki M, Saada M. Eosiopenia <100Ml as a marker of active COVID-19: An observational prospective study. J Microbiol Immunol Infect. 2021;54(1):61-8. [Link] [DOI:10.1016/j.jmii.2020.12.005] [PMID] [PMCID]
23. Khoury P, Stokes K, Gadkari M, Michelle A. Glucocorticosteroid-induce osteopenia in humans can be linked to early transcriptional events. Allergy. 2018;73(10):2076-9. [Link] [DOI:10.1111/all.13497] [PMID] [PMCID]
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Kadhim T, Abdulilah H. Eosinopenia; a Predictor of Non-Respiratory COVID-19. Iran J War Public Health. 2021; 13 (3) :185-188
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Volume 13, Issue 3 (2021) Back to browse issues page
مجله طب جانباز Iranian Journal of War and Public Health
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