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Volume 16, Issue 1 (2024)
Iran J War Public Health 2024, 16(1): 1001-1011 |
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Received: 2023/10/31 | Accepted: 2024/03/4 | Published: 2024/01/10
Received: 2023/10/31 | Accepted: 2024/03/4 | Published: 2024/01/10
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Sarah Hashim Kazem, Murtada Hafedh Hussein. Immunological Role for IL 17A and some biochemical factor in patient with SLE in Relation to Renal failure. Iran J War Public Health 2024; 16 (1) :1001-1011
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Abstract (148 Views)
The current investigation aims to study certain parameters including, IL-17A, creatinine ,lymphocyte, and basophile in patients who suffer from SLE renal failure for comparing them with healthy control groups. The study was done on 105 patients (35 males, 70 females) who are confirmed to have SLE in Thi-Qar Province, southern of Iraq. The researchers withdraw 5ml of venous blood from 50 healthy control group to conduct three tests; immune tests to find out the amount of IL-17A (ELISA), biochemical tests to find out the amount of creatinine (colorimetric method), and CBC tests to find out the number of lymphocytes and basophils. The findings revealed that the total SLE illness rate was 83%, with females having a higher infection rate (66.67%) than males (33.33%). Significant variations were identified between sexes. Moreover, it is shown that there is a considerable increase in the level of IL17A and the amount of creatinine which was higher than those of healthy control. Finally, it is demonstrated that females suffer from this disease in age of 13-45 more than males. Compared to healthy group, the level of IL -17A and the creatinine were increased in some patients whereas the lymphocyte and basophile were decreased in some others. Thus, it is concluded that the level of IL17A, creatinine, lymphocyte, and basophie play a fundamental role in the SLE Pathogeneses.
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