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Volume 15, Issue 4 (2023)
Iran J War Public Health 2023, 15(4): 429-433 |
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Ethics code: 141/KEPK-J/VIII/2022
History
Received: 2023/08/10 | Accepted: 2024/01/18 | Published: 2024/01/30
Received: 2023/08/10 | Accepted: 2024/01/18 | Published: 2024/01/30
How to cite this article
Hussein M, Safar A, Khalaf M, Mahmood M. Immunological and Biochemical Glimpses of Giardiasis in Thalassemic Patients. Iran J War Public Health 2023; 15 (4) :429-433
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1- Department of Pathological Analysis, College of Science, Thi-Qar University, Thi-Qar, Iraq
2- Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq
3- Department of Pathological Analytics Science, College of Applied Medical Science, Shatrah University, Thi-Qar, Iraq
2- Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq
3- Department of Pathological Analytics Science, College of Applied Medical Science, Shatrah University, Thi-Qar, Iraq
Abstract (196 Views)
Aims: The present work seeks to ascertain immunological and biochemical characteristics in thalassemic individuals who have contracted giardiasis.
Materials & Methods: This experimental study was conducted at the Thalassemia Center in Thi-Qar province, Iraq, in 2022. Fifty patients (21 males and 29 females) and 20 healthy controls were investigated. Of the patients’ group, twenty-five were thalassemic and had giardiasis. The other 14 patients were thalassemic and free of giardia infection, and the remaining 11 patients were non-thalassemic but had giardia infection. Five ml of venous blood from each participant was withdrawn to determine WBCs, neutrophil activity, and levels of IL-6, iron, ferritin, and transferrin.
Findings: The levels of interleukin-6 in the three patient groups (28.20, 23.29, and 30.94pg/ml) were considerably higher than those in healthy controls (16.09pg/ml). In patient groups, there was a notable rise in WBCs but a notable fall in neutrophil activity. Additionally, a substantial increase in iron and ferritin was found, although transferrin was lower in the patients than in the control group.
Conclusion: The thalassemia and giardia patients have greater iron and ferritin levels but much lower transferrin levels than the healthy individuals.
Materials & Methods: This experimental study was conducted at the Thalassemia Center in Thi-Qar province, Iraq, in 2022. Fifty patients (21 males and 29 females) and 20 healthy controls were investigated. Of the patients’ group, twenty-five were thalassemic and had giardiasis. The other 14 patients were thalassemic and free of giardia infection, and the remaining 11 patients were non-thalassemic but had giardia infection. Five ml of venous blood from each participant was withdrawn to determine WBCs, neutrophil activity, and levels of IL-6, iron, ferritin, and transferrin.
Findings: The levels of interleukin-6 in the three patient groups (28.20, 23.29, and 30.94pg/ml) were considerably higher than those in healthy controls (16.09pg/ml). In patient groups, there was a notable rise in WBCs but a notable fall in neutrophil activity. Additionally, a substantial increase in iron and ferritin was found, although transferrin was lower in the patients than in the control group.
Conclusion: The thalassemia and giardia patients have greater iron and ferritin levels but much lower transferrin levels than the healthy individuals.
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