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Iran J War Public Health 2022, 14(4): 4-4 Back to browse issues page
The Histological and Enzymatic Reaction of Carbamazepine Drug – Induced Liver Injury as a Biomarker of Male Mice
Dhuha Adel Kareem *1, Alaa H. Sadoon2, Majdi F. Majeed2, Basil A. Abbas2
1- College of Veterinary Medicine, University of Basrah, Iraq , duha.adel@uobasrah.edu.iq
2- College of Veterinary Medicine, University of Basrah, Iraq
Abstract:   (26 Views)
Liver injury induced by the synthetic drug is a main apprehension for many pharmaceutical companies to obtain medicines with a high level of safety through continuous development in the international clinical therapy industry. Carbamazepine (CBZ) treatment is more of the safest drugs for its users, but found that a number of these patients may develop cases of acute hepatitis. We in this work objective were  side effects evaluate of the Carbamazepine of liver injury and elucidated the mechanism accounting for the liver toxicity of Carbamazepine in the mice Mus musculus L. (BALB/C) sex male, as a model was spliced into three groups as the following, the control was orally administered by 1 ml normal saline, the lower dose group was orally administered by 2.85 mg/kg/day, while the higher dose group was orally administered with 5.7 mg/kg/day, the experimental period was 30 days. The analysis of histological evaluation was observed via severe liver damage and acute inflammation of the hepatic tissue in mice that CBZ orally administered, while the analysis of serum concentration of liver enzyme and coenzyme (ALT, AST, GSH, GR, and GST), show a significant increase compared with the control group. However, The results obtained can be considered as a database that uses biomarkers that warn of pre-sensitivity for some patients to taking CBZ, also results confirmed that the Carbamazepine treatment may change the hepatic capacity for the detoxification of many toxic compounds from endogenous or exogenous. 
 
Keywords: Carbamazepine, Histology, Liver, ALT, AST, GSH, GR, GST
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Article Type: Original Research | Subject: Veterans or Handicapped Health
Received: 2022/07/28 | Accepted: 2022/10/23 | Published: 2022/11/1
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Kareem D A, Sadoon A H, Majeed M F, Abbas B A. The Histological and Enzymatic Reaction of Carbamazepine Drug – Induced Liver Injury as a Biomarker of Male Mice. Iran J War Public Health 2022; 14 (4) :4-4
URL: http://ijwph.ir/article-1-1252-en.html


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Volume 14, Issue 4 (2022) Back to browse issues page
مجله طب جانباز Iranian Journal of War and Public Health
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