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Hepato-protective effects of coenzyme Q10 against amoxiclav induced hepatotoxicity in rat model
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| Fadhaa Abdulameer Ghafil, Zahraa Abed Al-kareem1, Sahar Abdulredha Majeed, Noor Dheyaa Aziz, Suaad Mohammed Hassan Rasheed * |
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Abstract: (49 Views) |
Objective: Amoxiclav antibiotic is a commonly prescribed medication for many medical situations, it might be complicated by hepatic toxic effects that is either dose or duration related or an idiosyncratic reaction. Co q10 is a potent vitamin like material with an antioxidant properties, it can exerts a beneficial hepatocellular effects by reducing the drug toxicity.
Materials: Twenty four albino male rats weighting between 150-250 gwere separated randomly into four groups each consists of six animals maintained in the animal house of College of pharmacy, Kerbala University in which the control group were given normal saline,Amoxiclav group: were given 30 mg/Kg/day of amoxiclav orally for 30 days, Amoxiclav and Co-enzyme Q10 group: each animal was given orally 30 mg/Kg of amoxiclav, and 100 mg/Kg Co-enzyme Q10 orally daily for 30 days, and Co-enzyme Q10 group: Each rat in this group was given 100 mg/Kg Co-enzyme Q10 orally daily for 30 days. At the end of the experiment the animals were anesthetized then scarified for the assessment of serum liver enzymes as well as liver tissue samples were obtained for histopathological study.
Results: Liver function parameters manifested by ALT, AST, ALP, and TSB were significantly elevated in the animal group treated with amoxicalv together with hepatocellular necrosis and congestion.Concomitant treatment of animal group with the anti-oxidant coq10 together with amoxiclav was significantly reduce the liver enzymes as well as improvement of hepatocellular congestion and inflammation.
Conclusion: Coq10 is a potent anti-inflammatory and anti-oxidant agent that can be used to reduce hepatotoxic effect of amoxiclav antibiotic.
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| Keywords: Amoxiclv, Coq10, hepatotoxicity, rat model. |
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Full-Text [PDF 655 kb]
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Article Type: Original Research |
Subject:
Epidemiology and Statistics of War/Accident Related Injuries
Received: 2022/10/21 | Accepted: 2023/02/20 | Published: 2023/03/1
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