[Home ] [Archive]    
:: Current Issue :: Search :: Submit an Article ::
:: Volume 14, Issue 3 (2022) ::
Iran J War Public Health 2022, 14(3): 257-262 Back to browse issues page
Peculiarities of Clinical and Morphological Characteristics of Patients on the Local-advanced Malignant Tumors of the Thyroid Gland
I. Deineko *
Endocrine Surgery Center, Dnipropetrovsk Regional Clinical Hospital named after. І.І. Mechnikov, Dnipro, Ukraine , deineko9246@uohk.com.cn
Abstract:   (494 Views)
Aims: The main purpose of the study is to study and compare clinical and morphological characteristics, as well as the results of comprehensive treatment of patients with locally advanced malignant thyroid tumors T4a and T4b stage, compared with tumors without T1-3 invasions, to determine the main factors influencing the prognosis disease.
Material & Methods: The study groups included 120 patients with invasive locally-advanced malignant tumors of the thyroid gland of category T4a and 35 patients of category T4b. Also, for comparison of general and morphological characteristics, the control group of patients with non-invasive locally-advanced malignant tumors of the thyroid gland, or with the initial invasion of pre-thyroid muscles of category T1-3, which made up 1985 patients, was studied.
Findings: It was found that depending on the prevalence and degree of tumor invasion, the average age of patients increased, the number of men in groups increased, and the number of patients with regional and distant metastases increased, which worsened the prognosis. The most frequent localization of the invasion of the tumor of the thyroid gland was the invasion in the upper respiratory tract, namely, the invasion in the trachea, due to the close location of the thyroid gland around the trachea.
Conclusion: Aggressive surgical interventions in complex treatment allows in cases of well-differentiated tumors to significantly improve survival rates and reduce recurrence. Also, the use of radical methods of surgery improved the efficiency of treatment of the moderately differentiated tumors of the thyroid gland. Not looking at the use of aggressive radical surgery in the complex treatment of patients, the worst indicators remain in cases of moderate and poorly differentiated forms of the disease, but significantly improved quality and life expectancy, which is also important in cases of low morphological structure.
Article number: 2
Keywords: Thyroid Cancer [MeSH], Neoplasm Invasiveness [MeSH], Neck [MeSH], Mediastinum [MeSH], Treatment Outcome [MeSH]
Full-Text [PDF 509 kb]   (308 Downloads) |   |   Full-Text (HTML)  (36 Views)  
Article Type: Original Research | Subject: Diagnosis and Treatment of Veterans or Handicapped Diseases
Received: 2022/03/21 | Accepted: 2022/05/27 | Published: 2022/07/28
1. Ilderbayeva G, Zhetpisbaev B, Ilderbayev О, Taldykbayev Zh, Bekeeva S. Metabolic processes of organism in remote period after the combined effects of radiation and emotional stress. Georg Med News. 2016;250:76-82. [Link]
2. Fedorenko ZP, Gulak LO, Mikhailovich YU. Cancer in Ukraine: 2018-2019. Bull Natl Cancer Regist Ukr. 2020;12:58-9. [Link]
3. Dmytriiev D, Dmytriiev K, Stoliarchuk O, Semenenko A. Multiple organ dysfunction syndrome: What do we know about pain management? A narrative review. Anaesth Pain Intensive Care. 2019;23(1):84-91. [Link]
4. Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, et al. 2015 American Thyroid Association Management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid. 2016;26(1):1-133. [Link] [DOI:10.1089/thy.2015.0020]
5. Svyatova GS, Abil'Dinova GZh, Berezina GM. The frequency, dynamics, and structure of congenital malformations in populations under long-term exposure to ionizing radiation. Genetika. 2001;37(12):1696-704. [Russian] [Link] [DOI:10.1023/A:1013256231476]
6. Tusupkaliev BT, Zhumalina AK, Zhekeyeva BA, Baizhanova RM. The state of proinflammatory and anti-inflammatory cytokines in blood serum of infants with low birth weight in the prsesence of intrauterine infection. Int J Pharm Technol. 2016;8(2):13676-93. [Link]
7. Ahn HS, Kim HJ, Kim KH, Lee YS, Han SJ, Kim Y, et al. Thyroid cancer screening in South Korea increases detection of papillary cancers with no impact on other subtypes or thyroid cancer mortality. Thyroid. 2016;26(11):1535-40. [Link] [DOI:10.1089/thy.2016.0075]
8. Sharma A, Jasim S, Reading CC, Ristow KM, Villasboas Bisneto JC, Habermann TM, et al. Clinical presentation and diagnostic challenges of thyroid lymphoma: a cohort study. Thyroid. 2016;26(8):1061-7. [Link] [DOI:10.1089/thy.2016.0095]
9. Roka R. Surgical treatment of locally advanced thyroid cancer. Innov Surg Sci. 2020;5(1-2):27-34. [Link] [DOI:10.1515/iss-2020-0012]
10. Gay S, Monti E, Trambaiolo Antonelli C, Mora M, Spina B, Ansaldo G, et al. Case report: lenvatinib in neoadjuvant setting in a patient affected by invasive poorly differentiated thyroid carcinoma. Future Oncol. 2019;15(24s):13-9. [Link] [DOI:10.2217/fon-2019-0099]
11. Avenia N, Vannucci J, Monacelli M, Lucchini R, Polistena A, Santoprete S, et al. Thyroid cancer invading the airway: diagnosis and management. Int J Surg. 2016;28(1):S75-8. [Link] [DOI:10.1016/j.ijsu.2015.12.036]
12. Ríos A, Rodríguez JM, Ferri B, Matínez-Barba E, Febrero B, Parrilla P. Are prognostic scoring systems of value in patients with follicular thyroid carcinoma?. Eur J Endocrinol. 2013;169(6):821-7. [Link] [DOI:10.1530/EJE-13-0372]
13. Lloyd RV, Osamura RY, Kloppel G, Rosai J, editors. WHO classification tumors of endocrine organs. Geneva: World Health Organization; 2017. [Link]
14. Polatova DSh, Islamov UF, Davletov RR, Savkin AV, Sharipov MM. Oncologic outcomes of pelvic bone sarcomas surgical. Int J Health Sci. 2021;5(3):252-9. [Link] [DOI:10.53730/ijhs.v5n3.1467]
15. Lee GH, Kang JY. Surgical treatment in locally advanced thyroid cancer - trachea, larynx, esophagus invasion management. Int J Thyroidol. 2018;11(2):99-108. [Link] [DOI:10.11106/ijt.2018.11.2.99]
16. Abboud B, Abou Zeid H, Rohbane R, Jabbour H, Baradhi A. Surgical management and prognosis of thyroid carcinomas invading adjacent structures. Otorhinolaryngol Head Neck Sur. 2016:2. [Link] [DOI:10.15761/OHNS.1000125]
17. Kim TH, Kim YN, Kim HI, Park SY, Choe JH, Kim JH, Kim JS, Oh YL, Hahn SY, Shin JH, Kim K, Jeong JG, Kim SW, Chung JH. Prognostic value of the eighth edition AJCC TNM classification for differentiated thyroid carcinoma. Oral Oncol. 2017;71:81-6. [Link] [DOI:10.1016/j.oraloncology.2017.06.004]
18. Metere A, Aceti V, Giacomelli L. The surgical management of locally advanced well-differentiated thyroid carcinoma: changes over the years according to the AJCC 8th edition cancer staging manual. Thyroid Res. 2019;12:10. [Link] [DOI:10.1186/s13044-019-0071-3]
19. Tussupkaliev B, Zhumalina A, Zhekeyeva B, Sergazina T. The content of some essential micronutrients in infants with low birth weight with intrauterine herpes infection. Georg Med News. 2016;253:67-72. [Link]
20. Tatenov AM, Tuleuhanov ST, Amanbayeva MB. Research of the mechanism of recognition of cancercells by T-lymphocytes of immune system. Physics and chemistry of this mechanism. Res J Med Sci. 2015;9(4):237-9. [Link]
21. Banyra O, Sheremeta R, Shulyak A. Strangulation of the penis: two case reports. Cent Eur J Urol. 2013;66(2):242-5. [Link] [DOI:10.5173/ceju.2013.04.art2]
22. Fugazzola L, Elisei R, Fuhrer D, Jarzab B, Leboulleux S, Newbold K, et al. 2019 European Thyroid Association guidelines for the treatment and follow-up of advanced radioiodine-refractory thyroid cancer. Eur Thyroid J. 2019;8(5):227-45. [Link] [DOI:10.1159/000502229]
23. Li J, Yang GZ, Gao LX, Yan WX, Jin H, Li L. Hyalinizing trabecular tumor of the thyroid gland: case report and review of the literature. Exp Ther Med. 2012;3(6):1015-7. [Link] [DOI:10.3892/etm.2012.529]
24. Fujimoto N, Matsuu-Matsuyama M, Nakashima M. Single neonatal irradiation induces long-term gene expression changes in the thyroid gland, which may be involved in the tumorigenesis. Sci Rep. 2021;11(1):23620. [Link] [DOI:10.1038/s41598-021-03012-5]
25. Studeny T, Kratzer W, Schmidberger J, Graeter T, Barth TFE, Hillenbrand A. Analysis of vascularization in thyroid gland nodes with superb microvascular imaging (SMI) and CD34 expression histology: a pilot study. BMC Med Imaging. 2021;21:159. [Link] [DOI:10.1186/s12880-021-00690-5]
Send email to the article author

Add your comments about this article
Your username or Email:


XML     Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Deineko I. Peculiarities of Clinical and Morphological Characteristics of Patients on the Local-advanced Malignant Tumors of the Thyroid Gland. Iran J War Public Health 2022; 14 (3) :257-262
URL: http://ijwph.ir/article-1-1177-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 14, Issue 3 (2022) Back to browse issues page
مجله طب جانباز Iranian Journal of War and Public Health
Persian site map - English site map - Created in 0.04 seconds with 31 queries by YEKTAWEB 4570