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Volume 18, Issue 1 (2026)
Iran J War Public Health 2026, 18(1): 1001-1011 |
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Received: 2026/01/1 | Accepted: 2026/01/28 | Published: 2026/01/29
Received: 2026/01/1 | Accepted: 2026/01/28 | Published: 2026/01/29
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Dawood S, Nader M. Associations of miR-146a Gene Expression with inflammation of Type 2 Diabetes Mellitus in a Sample of Iraqi Patients. Iran J War Public Health 2026; 18 (1) :1001-1011
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URL: http://ijwph.ir/article-1-1728-en.html
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Abstract (124 Views)
The prevalence of type 2 diabetes mellitus (T2DM) is increasing dramatically worldwide. Dysregulation of microRNA (miRNA) as key regulators of gene expression, has been reported in numerous diseases including diabetes. The aim of this study was to investigate the expression levels of miRNA-146a in diabetic patients and in healthy individuals, and to determine whether the changes in the level of these miRNAs are reliable biomarkers in diagnosis, prognosis, and pathogenesis of T2DM. Additionally, we examined the relationship between miRNA levels and serum concentrations of inflammatory factors including tumor necrosis factor alpha (TNF-α) and Human Interleukin 1 Beta( IL1b) as well as insulin resistance. In this case-control study, participants (n = 150) were allocated to two groups (n = 100/group): T2DM, and (n = 50/group):healthy individuals as control (males and females, age: 40–70, body mass index: 25–35). Expression of miRNA was determined by real-time polymerase chain reaction (RT-PCR). Furthermore, serum concentrations of TNF-α, IL1b and fasting insulin were measured by enzyme-linked immunosorbent assay. Homeostatic model assessment for insulin resistance (HOMA-IR) was calculated as an indicator of insulin resistance. miR-146a was lower in diabetic patients, as evidenced by higher ΔCt values (P < 0.01). Furthermore, The pro-inflammatory cytokine levels were much higher among diabetic patients than in controls. That is, IL1B was markedly higher in diabetics (median: 93.9 pg/mL, IQR: 50.1–122) than in controls (median: 65.9 pg/mL, IQR: 51.8–76.8), P < 0.01. Similarly, the TNF-α levels were markedly higher in diabetic individuals (median: 26.1 pg/mL, IQR: 17.1–31.6) than in healthy controls (median: 16.1 pg/mL, IQR: 13.5–20.9), P < 0.0001. These findings indicate an increased pro-inflammatory condition in type 2 diabetes mellitus patients.
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