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Volume 17, Issue 2 (2025)
Iran J War Public Health 2025, 17(2): 1001-1015 |
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History
Received: 2025/02/17 | Accepted: 2025/06/19
Received: 2025/02/17 | Accepted: 2025/06/19
How to cite this article
R.K. Abbas, Alsaadi J. A study of Clinical changes in Adiponectin, Leptin and Some Inflammatory Parameters in Obese Patients with Type-2 diabetes and Hypertension in Thi-Qar Province. Iran J War Public Health 2025; 17 (2) :1001-1015
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Authors
R.K. Abbas *1, J.H.H. Alsaadi2
1- Department of Chemistry, College of Science, University of Thi-Qar, Iraq , ruaa.kareem@utq.edu.iq
2- Department of Chemistry, College of Science, University of Thi-Qar, Iraq
2- Department of Chemistry, College of Science, University of Thi-Qar, Iraq
Abstract (79 Views)
Background: Obesity is a global health issue that significantly increases the risk of chronic diseases such as type 2 diabetes and hypertension. Understanding the biochemical changes involved help in early diagnosis and targeted treatment.
Objective: The current study was aimed to investigate the changes in adiponectin, leptin and some inflammatory factors in serum obese patients with Type-2 diabetes and hypertension in Thi-Qar province/ Iraq.
Material and method: The present study was conducted at the “Al-Nasiriya Teaching Hospital in Thi-Qar Governorate” and Biochemistry Laboratory in the “College of science” in the period between August (2024) to January (2025). The study included a total of 140 subjects (male and female), 105 patients diagnosed with obese (BMI ≥30) among them, and 35 as control with (BMI ˂25) and their ages range from (35–65) years. They divided into four groups as the following: Cont. group: included (35) normal healthy, Obes. group: Included (35) Just obese patients, ODM group: Included (35) obese diabetes patients and OHTN group: Included (35) obese hypertensive patients.
Results: the results in this study showed significant increase (P≤0.05) in (LEP), (Hs-CRP) and (IL-6) levels and significant decrease in (ADP) level in all patients’ groups in comparison with control group, whereas no significant change (p≤0.05) in serum HIF-1α in patients’ groups when compared with control group. While no significant deference in each serum (ADP), (LEP), (Hs-CRP), (IL-6) and (HIF-1α) levels between obese-DM group and obese-HTN group compared with obese group (p≤0.05).
Conclusion: This study concluded that the obese patients with T2DM and with HTN had high significant level of LEP and inflammatory factors and low significant level of ADP than control group.
Objective: The current study was aimed to investigate the changes in adiponectin, leptin and some inflammatory factors in serum obese patients with Type-2 diabetes and hypertension in Thi-Qar province/ Iraq.
Material and method: The present study was conducted at the “Al-Nasiriya Teaching Hospital in Thi-Qar Governorate” and Biochemistry Laboratory in the “College of science” in the period between August (2024) to January (2025). The study included a total of 140 subjects (male and female), 105 patients diagnosed with obese (BMI ≥30) among them, and 35 as control with (BMI ˂25) and their ages range from (35–65) years. They divided into four groups as the following: Cont. group: included (35) normal healthy, Obes. group: Included (35) Just obese patients, ODM group: Included (35) obese diabetes patients and OHTN group: Included (35) obese hypertensive patients.
Results: the results in this study showed significant increase (P≤0.05) in (LEP), (Hs-CRP) and (IL-6) levels and significant decrease in (ADP) level in all patients’ groups in comparison with control group, whereas no significant change (p≤0.05) in serum HIF-1α in patients’ groups when compared with control group. While no significant deference in each serum (ADP), (LEP), (Hs-CRP), (IL-6) and (HIF-1α) levels between obese-DM group and obese-HTN group compared with obese group (p≤0.05).
Conclusion: This study concluded that the obese patients with T2DM and with HTN had high significant level of LEP and inflammatory factors and low significant level of ADP than control group.
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