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Volume 17, Issue 4 (2025)
Iran J War Public Health 2025, 17(4): 383-389 |
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Received: 2025/09/6 | Accepted: 2025/10/21 | Published: 2025/11/20
Received: 2025/09/6 | Accepted: 2025/10/21 | Published: 2025/11/20
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Al-Rikabi H, Haji Ghasem Kashani M, Abiri E, Molaei Fard F, Altememy D. Effect of Tannic Acid on Apoptosis in the Testes of Mice Exposed to Mobile Phone Electromagnetic Waves. Iran J War Public Health 2025; 17 (4) :383-389
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1- Iraqi Ministry of Education, General Directorate of Education in Karbala Governorate, Karbala, Iraq
2- Department of Cellular-Molecular Biology, Faculty of Biology, Damghan University, Damghan, Iran
3- Department of Pharmaceutics, College of Pharmacy, Al-Zahraa University for Women, Karbala, Iraq
2- Department of Cellular-Molecular Biology, Faculty of Biology, Damghan University, Damghan, Iran
3- Department of Pharmaceutics, College of Pharmacy, Al-Zahraa University for Women, Karbala, Iraq
Abstract (360 Views)
Aims: Tannic acid is a natural polyphenolic compound with antioxidant, antibacterial, and anti-inflammatory properties. This study investigated the anti-apoptotic effect of tannic acid on the testicular tissue of mice exposed to mobile phone radiofrequency waves.
Materials & Methods: In this experimental study, 30 adult male Balb/c mice were randomly divided into five groups: Control (no treatment), tannic acid (20mg/kg intraperitoneally every other day, 3 days per week), sham (physiological saline instead of tannic acid; conditions similar to the tannic acid group), electromagnetic field (mice exposed to 900MHz electromagnetic waves for 8 hours daily (from 9:30 AM to 5:30 PM)), electromagnetic field+tannic acid (mice exposed to electromagnetic waves as in the previous group and also receiving tannic acid at 20mg/kg every other day, 3 days per week). After 35 days of treatment, the animals were sacrificed, and the left testes were stored at -70°C for real-time polymerase chain reaction analysis of apoptosis-related genes (Apaf-1, Bad, and Foxo3a).
Findings: In the EMF group, a significant increase in the expression of Foxo3a, Bad, and Apaf-1 was observed compared with the sham group, indicating the destructive effect of electromagnetic waves on testicular tissue. A significant decrease in the expression of these genes was observed in the electromagnetic field+tannic acid group compared with the electromagnetic waves group.
Conclusion: Tannic acid reduces apoptosis in the testes of mice exposed to radiofrequency electromagnetic fields, and exposure to 900MHz radiofrequency waves intensifies apoptosis in testicular tissue.
Materials & Methods: In this experimental study, 30 adult male Balb/c mice were randomly divided into five groups: Control (no treatment), tannic acid (20mg/kg intraperitoneally every other day, 3 days per week), sham (physiological saline instead of tannic acid; conditions similar to the tannic acid group), electromagnetic field (mice exposed to 900MHz electromagnetic waves for 8 hours daily (from 9:30 AM to 5:30 PM)), electromagnetic field+tannic acid (mice exposed to electromagnetic waves as in the previous group and also receiving tannic acid at 20mg/kg every other day, 3 days per week). After 35 days of treatment, the animals were sacrificed, and the left testes were stored at -70°C for real-time polymerase chain reaction analysis of apoptosis-related genes (Apaf-1, Bad, and Foxo3a).
Findings: In the EMF group, a significant increase in the expression of Foxo3a, Bad, and Apaf-1 was observed compared with the sham group, indicating the destructive effect of electromagnetic waves on testicular tissue. A significant decrease in the expression of these genes was observed in the electromagnetic field+tannic acid group compared with the electromagnetic waves group.
Conclusion: Tannic acid reduces apoptosis in the testes of mice exposed to radiofrequency electromagnetic fields, and exposure to 900MHz radiofrequency waves intensifies apoptosis in testicular tissue.
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