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Volume 15, Issue 4 (2023)
Iran J War Public Health 2023, 15(4): 323-327 |
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Received: 2023/05/26 | Accepted: 2023/10/9 | Published: 2023/12/19
Received: 2023/05/26 | Accepted: 2023/10/9 | Published: 2023/12/19
How to cite this article
Sherhan A, Saihood H. Role of Antibiotics in Reducing the Days of Hospitalization in Acute Severe Bronchial Asthma Patients. Iran J War Public Health 2023; 15 (4) :323-327
URL: http://ijwph.ir/article-1-1348-en.html
URL: http://ijwph.ir/article-1-1348-en.html
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Authors
A.A. Sherhan *1, H.A. Saihood2
1- Department of Medicine, Basrah College of Medicine, Basrah University, Basrah, Iraq
2- Basrah Health Directorate, Basrah, Iraq
2- Basrah Health Directorate, Basrah, Iraq
Abstract (646 Views)
Aims: Bronchial asthma is a chronic bronchospastic disease of the lung airway and one of the major causes of morbidity and mortality in childhood and adult age groups. This study aimed to investigate the role of antibiotics in managing acute asthmatic attacks in patients admitted to Al-Mawani General Hospital in Basrah, Iraq.
Instrument & Methods: This cross-sectional study was conducted on acute asthmatic patients admitted from January 2021 to January 2022 in Al-Mawani General Hospital in Basrah, Southern Iraq. Out of the patients, 70 subjects were selected by random sampling according to the Cochrane formula. The patient’s records were retrieved from AL-Mawani General Hospital. Data were analyzed using the Chi-square test through SPSS 18 software.
Findings: There was just a significant difference in the frequency of hypertension in comparing the goodness of fit between the subjects (p=0.045). There was an inverse relationship between the duration of hospitalization and single and combined medicine therapy by antibiotic. There was no significant association between the duration of asthma and single/combined medicine.
Conclusion: Amoxicillin and ceftriaxone as an additional treatment to standard therapy of acute severe asthma effectively reduces hospitalization of asthmatic patients.
Instrument & Methods: This cross-sectional study was conducted on acute asthmatic patients admitted from January 2021 to January 2022 in Al-Mawani General Hospital in Basrah, Southern Iraq. Out of the patients, 70 subjects were selected by random sampling according to the Cochrane formula. The patient’s records were retrieved from AL-Mawani General Hospital. Data were analyzed using the Chi-square test through SPSS 18 software.
Findings: There was just a significant difference in the frequency of hypertension in comparing the goodness of fit between the subjects (p=0.045). There was an inverse relationship between the duration of hospitalization and single and combined medicine therapy by antibiotic. There was no significant association between the duration of asthma and single/combined medicine.
Conclusion: Amoxicillin and ceftriaxone as an additional treatment to standard therapy of acute severe asthma effectively reduces hospitalization of asthmatic patients.
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References
1. Jindal SK, Gupta D, Aggarwal AN, Agarwal R. Guidelines for management of asthma at primary and secondary levels of health care in India (2005). Indian J Chest Dis Allied Sci. 2005;47(4):309-43. [Link]
2. Global Initiative for Asthma (GINA) [Internet]. Global strategy for asthma management and prevention [Cited 2019, 6 August]. Available from: http://search.ebscohost.com/login.aspx?direct=true&db=cin20&A.N.=118972966&site=ehost-live. [Link]
3. Teach SJ, Gill MA, Togias A, Sorkness CA, Arbes SJ, Calatroni A, et al. Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations. J Allergy Clin Immunol. 2015;136(6):1476-85. [Link] [DOI:10.1016/j.jaci.2015.09.008]
4. Trasande L, Thurston GD. The role of air pollution in asthma and other pediatric morbidities. J Allergy Clin Immunol. 2005;115(4):689-99. [Link] [DOI:10.1016/j.jaci.2005.01.056]
5. Rosser F, Brehm JM, Forno E, Acosta-Pérez E, Kurland K, Canino G, et al. Proximity to a major road, vitamin D insufficiency, and severe asthma exacerbations in Puerto Rican children. Am J Respir Crit Care Med. 2014;190(10):1190-1193. [Link] [DOI:10.1164/rccm.201408-1568LE]
6. Shmool JLC, Kubzansky LD, Newman OD, Spengler J, Shepard P, Clougherty JE. Social stressors and air pollution across New York City communities: A spatial approach for assessing correlations among multiple exposures. Environ Health. 2014;13(91). [Link] [DOI:10.1186/1476-069X-13-91]
7. Johnston SL, Pattemore PK, Sanderson G, Smith S, Lampe F, Josephs L, et al. Community study of the role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ. 1995;310:1225-1229. [Link] [DOI:10.1136/bmj.310.6989.1225]
8. Jackson DJ, Johnston SL. The role of viruses in acute exacerbations of asthma. J Allergy Clin Immunol. 2010;125(6):1178-87. [Link] [DOI:10.1016/j.jaci.2010.04.021]
9. Shah R, Saltoun CA. Chapter 14: Acute severe asthma (status asthmaticus). Allergy Asthma Proc. 33:147-50. [Link] [DOI:10.2500/aap.2012.33.3547]
10. SIGN (2019). British Guideline on the Management of Asthma. Scotland: SIGN. Available from: https://www.sign.ac.uk/our-guidelines/british-guideline-on-the-management-of-asthma/ [Link]
11. Parsons JP, Hallstrand TS, Mastronarde JG. An official American Thoracic Society clinical practice guideline: exercise-induced bronchoconstriction. Am J Respir Crit Care Med. 187(9):1016-27. [Link] [DOI:10.1164/rccm.201303-0437ST]
12. Jaffe A, Bush A. Anti-inflammatory effects of macrolides in lung disease. Pediatr Pulmonol. 2001;31(6):464-73. [Link] [DOI:10.1002/ppul.1076]
13. David A, Stempel MD. Determining the appropriate use of antibiotics for the treatment of acute asthma. J Allergy Clin Immunol Pract. 2019;7(2):P554-5. [Link] [DOI:10.1016/j.jaip.2018.10.029]
14. Global Initiative for Asthma (2018). GINA report: global strategy for asthma management. Available from: https://ginasthma.org/2018-gina-report-global-strategy-for-asthma-management-and-prevention [Link]
15. Stolbrink M, Bonnett LJ, Blakey JD. Antibiotic choice and duration associate with repeat prescriptions in infective asthma exacerbations. J Allergy Clin Immunol Pract. 2019;7:548-553 [Link] [DOI:10.1016/j.jaip.2018.07.049]
16. Rai SP, Patil AP, Vardhan V, Marwah V, Pethe M, Pandey IM. Best treatment guideline for bronchial asthma. Med J armed force india. 2007;63(3):264-8 [Link] [DOI:10.1016/S0377-1237(07)80151-1]
17. Kumar P, Clark ML. Kumar & Clark's clinical medicine (7th ed). Amsterdam: Elsevier; 2009. [Link]
18. Murk W, Risnes KR, Bracken MB. Prenatal or early life exposure to antibiotics and risk of childhood asthma: a systematic review. Pediatrics. 2011;127(6):1125-38. [Link] [DOI:10.1542/peds.2010-2092]
19. Neu J, Rushing J. Cesarean versus vaginal delivery: long-term infant outcomes and the hygiene hypothesis. Clin Perinatol. 2011;38(2):321-31. [Link] [DOI:10.1016/j.clp.2011.03.008]
20. Richard JM, Monica K, Hong Wei C, Eric AB, Gail HC. A link between chronic asthma and chronic infection. J Allergy Clin Immunol. 2001;107(4):595-601 [Link] [DOI:10.1067/mai.2001.113563]
21. Biscardi S, Mathie L, Elizabeth M, Florence M, Benedicte BF, Claire H, et al. Mycoplasma pneumoniae and asthma in children. Clin Infect Diseases. 2004; 38(10):1341-6. [Link] [DOI:10.1086/392498]
22. Sebastian LJ. Macrolide antibiotics and asthma treatment. J Allergy Clin Immunol. 2006;117(6):1233-6. [Link] [DOI:10.1016/j.jaci.2006.03.035]
23. Amsden GW. Anti-inflammatory effects of macrolides-an underappreciated benefit in the treatment of community-acquired respiratory tract infections and chronic inflammatory pulmonary conditions?. J Antimicrob Chemother. 2005;55(1):10-21. [Link] [DOI:10.1093/jac/dkh519]
24. Denholm R, Vand der Warf ET, Hay AD. Use of antibiotics and asthma medication for acute lower respiratory tract infections in people with and without asthma: retrospective cohort study. Respir Res. 2020;21(4). [Link] [DOI:10.1186/s12931-019-1233-5]