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Volume 12, Issue 4 (2020)
Iran J War Public Health 2020, 12(4): 259-265 |
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Received: 2020/10/13 | Accepted: 2020/12/6 | Published: 2020/11/30
Received: 2020/10/13 | Accepted: 2020/12/6 | Published: 2020/11/30
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Shahrabadi H, Haghighi A, Talebi S. Effects of Exercise Training on Improving the Immune System of Elderly at the Time of COVID-19: a Systematic Review. Iran J War Public Health 2020; 12 (4) :259-265
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1- Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran , h.shahrabadi@gmail.com
2- Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran
3- Department of Nursing Education, Faculty of Nursing and Midwifery, Medical University of Sabzevar, Sabzevar, Iran
2- Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran
3- Department of Nursing Education, Faculty of Nursing and Midwifery, Medical University of Sabzevar, Sabzevar, Iran
Abstract (3882 Views)
Aims: This study aimed to investigate the effect of exercise training to improve the immune system of the elderly at the time of COVID-19.
Information & Methods: This systematic review study was performed on articles published between 1999 and 2020, and their target group was elderly. Keywords were searched and evaluated by three people in PubMed, Scopus, Science Direct, Google Scholar, Magiran, and SID databases. Twenty-two articles were selected for research.
Findings: According to most studies' results, the leukocyte population decreased significantly or did not change in response to training. In most studies, the levels of T cells (CD3+), helper T cells (CD4+), killer T cells (CD8+), natural killers (CD56+), and B cells (CD19+) did not change. CD28+CD4+ cells after intervention either increased significantly or did not change in some studies. Naive T cells (CD45RA+) and memory T cells (CD45RO+) did not change in the studies. Natural killer cell cytotoxic activity (NKCA) also increased significantly or did not change. Interleukin-6 and tumor necrosis factor-alpha decreased significantly in all related studies, but on the other hand, interleukin-10 increased significantly. The amount of C-reactive protein decreased significantly in the two studies and did not change in the other two studies. Intercellular adhesion molecule-1(ICAM-1), vascular cell adhesion molecule (VCAM-1), and endothelin-1 decreased significantly in investigations. Salivary IgA secretion rate increased significantly in two studies. Salivary IgA concentration increased in two studies and did not change in the other two studies. Salivary IgA flow increased in one study and did not change in another study.
Conclusion: According to the results, regular moderate-intensity exercise training reduces inflammation and improves some safety indicators in the elderly. With immune system improvement through exercise training in the elderly, the ability of the elderly may increase for encountering COVID-19 infection, and the risk of acquiring severe COVID-19 and hospitalization and mortality rates related to this disease may reduce in the elderly.
Information & Methods: This systematic review study was performed on articles published between 1999 and 2020, and their target group was elderly. Keywords were searched and evaluated by three people in PubMed, Scopus, Science Direct, Google Scholar, Magiran, and SID databases. Twenty-two articles were selected for research.
Findings: According to most studies' results, the leukocyte population decreased significantly or did not change in response to training. In most studies, the levels of T cells (CD3+), helper T cells (CD4+), killer T cells (CD8+), natural killers (CD56+), and B cells (CD19+) did not change. CD28+CD4+ cells after intervention either increased significantly or did not change in some studies. Naive T cells (CD45RA+) and memory T cells (CD45RO+) did not change in the studies. Natural killer cell cytotoxic activity (NKCA) also increased significantly or did not change. Interleukin-6 and tumor necrosis factor-alpha decreased significantly in all related studies, but on the other hand, interleukin-10 increased significantly. The amount of C-reactive protein decreased significantly in the two studies and did not change in the other two studies. Intercellular adhesion molecule-1(ICAM-1), vascular cell adhesion molecule (VCAM-1), and endothelin-1 decreased significantly in investigations. Salivary IgA secretion rate increased significantly in two studies. Salivary IgA concentration increased in two studies and did not change in the other two studies. Salivary IgA flow increased in one study and did not change in another study.
Conclusion: According to the results, regular moderate-intensity exercise training reduces inflammation and improves some safety indicators in the elderly. With immune system improvement through exercise training in the elderly, the ability of the elderly may increase for encountering COVID-19 infection, and the risk of acquiring severe COVID-19 and hospitalization and mortality rates related to this disease may reduce in the elderly.
Keywords:
References
1. Chen Y, Liu Q, Guo D. Emerging coronaviruses: Genome structure, replication, and pathogenesis. J Med Virol. 2020;92(4):418-23. [DOI:10.1002/jmv.25681]
2. Rothana HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun. 2020;109:102433. [DOI:10.1016/j.jaut.2020.102433]
3. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. [DOI:10.1016/S0140-6736(20)30183-5]
4. Wu L, Liu J, Zhao X, Liu C, Wang W, Wang D, et al. Clinical characteristics of imported cases of COVID-19 in Jiangsu province: A multicenter descriptive study. Clin Infect Dis. 2020;71(15):706-12. [DOI:10.1093/cid/ciaa199]
5. Rodriguez-Morales AJ, Cardona-Ospina JA, Gutiérrez-Ocampo E, Villamizar-Peña R, Holguin-Rivera Y, Escalera-Antezana JP, et al. Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis. Travel Med Infect Dis. 2020;34:101623. [DOI:10.1016/j.tmaid.2020.101623]
6. Chen T, Wu D, Chen H, Yan W, Yang D, Chen G, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: Retrospective study. BMJ. 2020;368:m1091. [DOI:10.1136/bmj.m1091]
7. Majidi A, Moradi O. Effect of teaching the components of spiritual intelligence on death anxiety in the elderly. SALMAND Iran J Ageing. 2018;13(1):110-23. [Persian] [DOI:10.21859/sija.13.1.110]
8. Bahram ME, Pourvaghar MJ, Sadeh MR. Effect of 12 weeks of chosen Pilates exercise on the quality of life of healthy nonathletic people. J TOLOOE-BEHDASHT. 2014;13(1):93-103. [Persian]
9. Gleeson M. Immune function in sport and exercise. J Appl Psychol. 2007;103(2):693-9. [DOI:10.1152/japplphysiol.00008.2007]
10. Nejati V, Kordi R, Shojaei F. Evaluation of effective motivators and barriers of physical activity in the elderly. SALMAND Iran J Ageing. 2009;4(14):52-8. [Persian]
11. Asadi Shavaki M, Salehi L. The study of physical activity among elderly of Karaj city and its relationship with some the demographic factors. Alborz Univ Med Sci. 2016;5(4):259-66. [Persian] [DOI:10.18869/acadpub.aums.5.4.259]
12. Bahram ME, Siahkohian M, Bolboli L, Pourvaghar MJ. The effect of pilates training on immune markers in elderly men. J Health Promot Manag. 2020;9(2):56-66. [Persian]
13. Akbarpour-beni M, Alavi K. Impact of aerobic training on CD25, Interleukin-2 and salivary IgA in elderly men. FEYZ. 2012;16(1):24-30. [Persian]
14. Kabir B, Taghian F, Ghatreh Samani K. Effect of aerobic training on levels of Interleukin-18 and C-reactive protein in elderly men. J Shahrekord Univ Med Sci. 2014;16(3):8-15. [Persian]
15. Saremi A. Influence of 3 Months resistance training on C-reactive protein serum levels and muscle hypertrophy in elderly men. Salmand Iran J Ageing. 2012;7(3):30-7. [Persian]
16. Azamian Jazi A, Framarzi M, Safari Farsani F. Effects of aerobic training on soluble intercellular adhesion molecule-1 (sICAM-1) and lipid profile in overweight elderly women. J Exerc Physiol Phys Act. 2010;5:401-8. [Persian]
17. Sanian H, Matinhomaee H, Peeri M. The effect of circuit resistance training on plasma concentration of endothelin-1, nitric oxide and vascular diameter in elderly men. J Clin Res Paramed Sci. 2019;8(1):e80932. [DOI:10.5812/jcrps.80932]
18. Mir E, Attarzadeh Hosseini SR, Mir Sayeedi M, Hejazi K. The effects of eight weeks selected combined exercises on humoral immune and hematological index in inactive older men. SALMAND Iran J Ageing. 2016;11(1):20-9. [Persian] [DOI:10.21859/sija-110120]
19. Shimizu K, Suzuki N, Imai T, Aizawa K, Nanba H, Hanaoka Y, et al. Monocyte and T-cell responses to exercise training in elderly subjects. J Strength Cond Res. 2011;25(9):2565-72. [DOI:10.1519/JSC.0b013e3181fc5e67]
20. Shimizu K, Kimura F, Akimoto T, Akama T, Tanabe K, Nishijima T, et al. Effect of moderate exercise training on T-helper cell subpopulations in elderly people. Exerc Immunol Rev. 2008;14:24-37.
21. Kimura F, Shimizu K, Akama T, Akimoto T, Kuno S, Kono I. The Effects of walking exercise training on immune response in elderly subjects. Aging Health Promot. 2006;4(2):508-14. [DOI:10.5432/ijshs.4.508]
22. Akimoto T, Kumai Y, Akama E, Hayashi E, Murakami H, Soma R, et al. Effects of 12 months of exercise training on salivary secretory IgA levels in elderly subjects. Br J Sports Med. 2003;37(1):76-9. [DOI:10.1136/bjsm.37.1.76]
23. Raso V, Benard G, Da Silva Duarte AJ, Natale VM. Effect of resistance training on immunological parameters of healthy elderly women. Med Sci Sports Exerc. 2007;39(12):2152-9. [DOI:10.1249/mss.0b013e318156e9fa]
24. Santiago LAM , Neto LGL , Pereira GB, Leite RD, Mostarda CT, Monzani JOB, et al. Effects of resistance training on immunoinflammatory response, TNF-alpha gene expression, and body composition in elderly women. J Aging Res. 2018;2018:1467025. [DOI:10.1155/2018/1467025]
25. Santos RVT, Viana VAR, Boscolo RA, Marques VG, Santana MG, Lira FS, et al. Moderate exercise training modulates cytokine profile and sleep in elderly people. Cytokine. 2012;60(3):731-5. [DOI:10.1016/j.cyto.2012.07.028]
26. Woods JA, Ceddia MA, Wolters BW, Evans JK, Lu Q, McAuley E. Effects of 6 months of moderate aerobic exercise training on immune function in the elderly. Mech Ageing Dev. 1999;109:1-19. [DOI:10.1016/S0047-6374(99)00014-7]
27. McFarlin BK, Flynn MG, Phillips MD, Stewart LK, Timmerman KL. Chronic resistance exercise training improves natural killer cell activity in older women. J Gerontol A Biol Sci Med Sci. 2005;60(10):1315-8. [DOI:10.1093/gerona/60.10.1315]
28. Roh HT, Cho SY, So WY. A cross-sectional study evaluating the effects of resistance exercise on inflammation and neurotrophic factors in elderlywomen with obesity. J Clin Med. 2020;9(3):842. [DOI:10.3390/jcm9030842]
29. Ahn N, Kim K. The effects of resistance elastic bands exercises on salivary IgA and salivary cortisol levels in elderly women. Biomed Res. 2018;29(5). [DOI:10.4066/biomedicalresearch.29-17-2726]
30. Drela N, Kozdron E, Szczypiorski P. Moderate exercise may attenuate some aspects of immunosenescence. BMC Geriatr. 2004;4:8. [DOI:10.1186/1471-2318-4-8]
31. Abd El-Kader SM, Al-Shreef FM, Al-Jiffri OH. Impact of aerobic exercise versus resisted exercise on endothelial activation markers and inflammatory cytokines among elderly. Afr Health Sci. 2019;19(4):2874-80. [DOI:10.4314/ahs.v19i4.9]
32. Rosety I, Pery MT, Rosety J, Garcia N, Rodriguez-Pareja MA, Brenes-Martin F, et al. Circuit resistance training improved endothelial dysfunction in obese aged women. Nutr Hosp. 2016;33(1):17. [Spanish] [DOI:10.20960/nh.17]
33. Teixeira AM, Martins R, Martins M, Cunha MR. Changes in functional fitness, mood states and salivary IgA levels after exercise training for 19 weeks in elderly subjects. Int J Appl Sports Sci. 2008;20(2):16-26.
34. Song L, Kim YH, Chopra RK, Proust JJ, Nagel JE, Nordin AA, et al. Age-related effects in T cell activation and proliferation. Exp Gerontol. 1993;28(4-5):313-21. [DOI:10.1016/0531-5565(93)90058-L]
35. Mariani E, Sgobbi S, Meneghetti A, Tadolini M, Tarozzi A, Sinoppi M, et al. Perforins in human cytolytic cells: The effect of age. Mech Ageing Dev. 1996;92(2-3):195-209. [DOI:10.1016/S0047-6374(96)01829-5]
36. Boucher N, Dufeu-Duchesne T, Vicaut E, Farge D, Efros RB, Schächter F. CD28 expression in T cell aging and human longevity. Exp Gerontol. 1998;33(3):267-82. [DOI:10.1016/S0531-5565(97)00132-0]
37. Alberti S, Cevenini E, Ostan R, Capri M, Salvioli S, Bucci L, et al. Age-dependent modifications of Type 1 and Type 2 cytokines within virgin and memory CD4+ T cells in humans. Mech Ageing Dev. 2006;127(6):560-6. [DOI:10.1016/j.mad.2006.01.014]
38. Bian Y, Hiraoka S, Tomura M, Zhou XY, Yashiro-Ohhtani Y, Mori Y, et al. The capacity of the natural ligands for CD28 to drive IL-4 expression in naïve and antigen-primed CD4+ and CD8+ T cells. Int Immunol. 2005;17(1):73-83. [DOI:10.1093/intimm/dxh188]
39. McFarlin BK, Flynn MG, Stewart LK, Timmerman KL. Carbohydrate intake during endurance exercise increases natural killer cell responsiveness to IL-2. J Appl Physiol. 2004;96(1):271-5. [DOI:10.1152/japplphysiol.00585.2003]
40. Tsukui S, Kanda T, Nara M, Nishino M, Kondo T, Kobayashi I. Moderate-intensity regular exercise decreases serum tumor nec rosis factor-alpha and HbA1c levels in healthy women. Int J Obes Relat Metab Disord. 2000;24(9):1207-11. [DOI:10.1038/sj.ijo.0801373]
41. Matsumoto A, Seki Y, Watanabe R, Hayashi K, Johnston JA, Harada Y, et al. A role of suppressor of cytokine signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated interleukin 2 production. J Exp Med. 2003;197(4):425-36. [DOI:10.1084/jem.20020939]
42. Kohut ML, Thompson JR, Lee W, Cunnick JE. Exercise training-induced adaptations of immune response are mediated by beta-adrenergic receptors in aged but not young mice. J Appl Physiol. 2004;96(4):1312-22. [DOI:10.1152/japplphysiol.00792.2003]
43. Nobrega OT, Faleiros VP, Telles JL. Gerontology in the developing Brazil: Achievements and challenges in public policies. Geriatr Gerontol Int. 2009;9(2):135-9. [DOI:10.1111/j.1447-0594.2008.00499.x]
44. Amani Shalamzari S, Agha Alinejad H, Gharakhanlou R, Molanouri Shamsi M, Talebi Badrabadi K. The effect of body composition and physical activity on basal levels of insulin, glucose, IL-18, IL-6 & CRP and their relationship with insulin resistance. Iran J Endocrinol Metab. 2009;11(6):699-706. [Persian]
45. Timmerman KL, Flynn MG, Coen PM, Markofski MM, Pence BD. Exercise training-induced lowering of inflammatory (CD14+CD16+) monocytes: A role in the anti-inflammatory influence of exercise?. J Leukoc Biol. 2008;84(5):1271-8. [DOI:10.1189/jlb.0408244]
46. Wang J, Song H, Tang X, Yang Y, Vieira VJ, Niu Y, et al. Effect of exercise training intensity on murine T-regulatory cells and vaccination response. Scand J Med Sci Sports. 2012;22(5):643-52. [DOI:10.1111/j.1600-0838.2010.01288.x]
47. Barton M. Cholesterol and atherosclerosis: Modulation by oestrogen. Curr Opin Lipidol. 2013;24(3):214-20. [DOI:10.1097/MOL.0b013e3283613a94]
48. Nadaud S, Philippe M, Arnal JF, Michel JB, Soubrier F. Sustained increase in aortic endothelial nitric oxide synthase expression in vivo in a model of chronic high blood flow. Circ Res. 1996;79(4):857-63. [DOI:10.1161/01.RES.79.4.857]
49. Miletic ID, Schiffman SS, Miletic VD, Sattely-Miller EA. Salivary IgA secretion rate in young and elderly persons. Physiol Behav. 1996;60(1):243-8. [DOI:10.1016/0031-9384(95)02161-2]
50. Abdelbasset WK. Stay home: Role of physical exercise training in elderly individuals' ability to face the COVID-19 infection. J Immunol Res. 2020;2020:8375096. [DOI:10.1155/2020/8375096]
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