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Volume 18, Issue 2 (2026)
Iran J War Public Health 2026, 18(2): 1001-1006 |
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Received: 2026/05/31 | Accepted: 2026/06/17 | Published: 2026/07/19
Received: 2026/05/31 | Accepted: 2026/06/17 | Published: 2026/07/19
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Diagnostic Study of CD35 Protein-Gene As a Biochemical Variable To Prediction of Iraqi Hepatic Cancer Patients. Iran J War Public Health 2026; 18 (2) :1001-1006
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URL: http://ijwph.ir/article-1-1760-en.html
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Abstract (369 Views)
A number of cancers have been linked to the CD35 protein gene, which codes for a crucial molecule in inflammation and immunology. Hepatic carcinoma (HC) and CD35 polymorphisms have been linked in certain studies, however this is far from definitive. This research sought to examine the association between tag SNPs in CD35 and susceptibility to HC, as well as postoperative recurrence, to further knowledge of gene-environment interactions in HC.Of the 120 Iraqi participants surveyed for this research, 56 had HC and 64 were healthy. Several cancers have been linked to the CD35 protein gene, which codes for a crucial molecule in inflammation and immunology. Although some studies have indicated a correlation between hepatic carcinoma (HC) and CD35 polymorphisms, this is not yet definitive. This study examined CD35 tag SNPs and HC susceptibility and postoperative recurrence to better understand gene-environment interactions in HC. Our research included 120 Iraqis; 56 had HC and 64 were healthy. We used HaploView 4.2 software to pick three CD35 Tag SNPs (rs2296160, rs3849266 and rs7525160), and MALDI-TOF-MS was used for genotyping. Higher rates of HC were linked to CD35 rs7525160 mutant genotypes CC/CG. A stratification study showed that the CD35 rs7525160 CC/CG genotypes were significantly related with a pathological kind of poor HC prognosis and increased the incidence of HC in those under 60.The Cox proportional hazard ratio model shows that the rs7525160 CC/CG genotype increases post-surgery HC recurrence. Finally, the CD35 rs7525160 polymorphism may affect Iraqi HC incidence and prognosis.