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Volume 17, Issue 4 (2025)
Iran J War Public Health 2025, 17(4): 1001-1007 |
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Received: 2025/12/22 | Accepted: 2026/01/1 | Published: 2025/11/19
Received: 2025/12/22 | Accepted: 2026/01/1 | Published: 2025/11/19
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Hussein B A. Effects of Different Levels of Dietary Zinc Supplementation on Serum Proteins, Liver Enzymes, Antioxidant Status, and Blood Metabolites in Male New Zealand White Rabbits. Iran J War Public Health 2025; 17 (4) :1001-1007
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Abstract (8 Views)
Aim: The present experiment investigated the influence of different dietary zinc levels on selected physiological indices, putative immune-related markers, liver enzyme activity and blood metabolites in male New Zealand White rabbits. Zinc is an essential trace element involved in numerous metabolic and regulatory processes in both humans and animals.
Material and Methods: Thirty New Zealand White male rabbits, 6–8 weeks of age, were randomly assigned to three groups (n = 10 per group) and maintained under standard laboratory conditions for 25 days. The control group received a basal diet, while the two treatment groups were fed diets supplemented with 6 or 9 mg zinc/kg feed.
Findings: At 6 mg/kg, zinc supplementation increased serum albumin and total protein concentrations, indicating improved protein status and antioxidant protection. The higher level (9 mg/kg) significantly reduced serum GPT and GOT activities, suggesting better hepatic function and less hepatocellular damage, although only minor changes were observed in GSH and MDA values. Zinc-supplemented rabbits showed decreased blood glucose concentrations, consistent with enhanced insulin sensitivity and more efficient carbohydrate metabolism. In contrast, the higher zinc dose was associated with slight elevations in serum cholesterol and urea, which may reflect an emerging metabolic imbalance.
Conclusion: Overall, moderate dietary zinc supplementation appears to support liver function and metabolic health in adult male rabbits while maximising physiological benefits and minimising potential adverse effects.
Material and Methods: Thirty New Zealand White male rabbits, 6–8 weeks of age, were randomly assigned to three groups (n = 10 per group) and maintained under standard laboratory conditions for 25 days. The control group received a basal diet, while the two treatment groups were fed diets supplemented with 6 or 9 mg zinc/kg feed.
Findings: At 6 mg/kg, zinc supplementation increased serum albumin and total protein concentrations, indicating improved protein status and antioxidant protection. The higher level (9 mg/kg) significantly reduced serum GPT and GOT activities, suggesting better hepatic function and less hepatocellular damage, although only minor changes were observed in GSH and MDA values. Zinc-supplemented rabbits showed decreased blood glucose concentrations, consistent with enhanced insulin sensitivity and more efficient carbohydrate metabolism. In contrast, the higher zinc dose was associated with slight elevations in serum cholesterol and urea, which may reflect an emerging metabolic imbalance.
Conclusion: Overall, moderate dietary zinc supplementation appears to support liver function and metabolic health in adult male rabbits while maximising physiological benefits and minimising potential adverse effects.
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