other آمار و اپیدمیولوژی معلولیت‌های ناشی از جنگ/حادثه Epidemiology and Statistics of War/Accident Related Injuries پژوهشی اصيل Original Research <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span style="font-family:&quot;Cambria&quot;,serif"><span style="color:#f79646">Aims</span></span></span></b><b><span style="font-size:10.0pt"><span style="background:white"><span style="font-family:&quot;Cambria&quot;,serif"><span style="color:#f79646"><span style="letter-spacing:.05pt">:</span></span></span></span></span></b> <span style="font-size:10.0pt"><span style="font-family:&quot;Cambria&quot;,serif"><span style="letter-spacing:.05pt">Schiff bases are compounds known for their anti-cancer properties. The combination of Schiff bases with metals enhances their anticancer effects. The current study was conducted to determine the apoptotic effect of Schiff base compounds derived from 2-hydroxynaphthaldehyde and 2-chloroethylamine, along with manganese complexes, on HepG2 cells compared to mesenchymal stem cells at the Damghan Faculty of Chemistry, Iran.</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span style="background:white"><span style="font-family:&quot;Cambria&quot;,serif"><span style="color:#f79646"><span style="letter-spacing:.05pt">Materials & Methods:</span></span></span></span></span></b> <span style="font-size:10.0pt"><span style="font-family:&quot;Cambria&quot;,serif"><span style="letter-spacing:.05pt">In this</span></span></span> <span style="font-size:10.0pt"><span style="font-family:&quot;Cambria&quot;,serif"><span style="letter-spacing:.05pt">experimental study, three Schiff base compounds, naph-Br, naph(br)₂Mn, and naph(br)₂Ni, were used to investigate anticancer properties on HepG2 cancer cells and compare them with adipose tissue stem cells. HepG2 and adipose tissue-derived stem cells were treated for 24 hours with these compounds at concentrations of 100, 200, 300, 400, 500, 600, and 700&micro;M. Cell proliferation and survival were evaluated using hemocytometry, MTT, and Ki-67 immunocytochemistry methods.</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span style="background:white"><span style="font-family:&quot;Cambria&quot;,serif"><span style="color:#f79646"><span style="letter-spacing:.05pt">Findings:</span></span></span></span></span></b> <a name="_Hlk162484990"><span style="font-size:10.0pt"><span style="font-family:&quot;Cambria&quot;,serif"><span style="letter-spacing:.05pt">Schiff base compounds reduced the proliferation rate of HepG2 cancer cells and adipose tissue-derived stem cells at concentrations of 200, 300, 400, and 500&micro;M, while increasing the rate compared to the control group.</span></span></span></a></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span style="background:white"><span style="font-family:&quot;Cambria&quot;,serif"><span style="color:#f79646"><span style="letter-spacing:.05pt">Conclusion</span></span></span></span></span></b><b><span style="font-size:10.0pt"><span style="background:white"><span style="font-family:&quot;Cambria&quot;,serif"><span style="color:#f79646"><span style="letter-spacing:.05pt">:</span></span></span></span></span></b> <span style="font-size:10.0pt"><span style="font-family:&quot;Cambria&quot;,serif"><span style="letter-spacing:.05pt">Schiff base compounds inhibit the proliferation of cancer cells and induce apoptosis at multiple concentrations, demonstrating their versatility and efficacy in combating cancer. </span></span></span></span></span></span></span><br> &nbsp; HepG2 Cells,Adipose Tissue Stem Cells (ASC),Schiff Base,Apoptosis,Cancer,Stem Cells,Rat, 279 291 http://ijwph.ir/browse.php?a_code=A-10-2366-1&slc_lang=other&sid=1 O.N. Wennas 15300319475328460028430 15300319475328460028430 No Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Zahraa University for Women, Karbala, Iraq M. Haji Ghasem Kashani 15300319475328460028431 15300319475328460028431 Yes Department of Cellular and Molecular Biology, Faculty of Biology and Institute of Biological Sciences, Damghan University, Damghan, Iran E. Abiri 15300319475328460028432 15300319475328460028432 No Department of Cellular and Molecular Biology, Faculty of Biology and Institute of Biological Sciences, Damghan University, Damghan, Iran D. Altememy 15300319475328460028433 15300319475328460028433 No Department of Pharmaceutics, Faculty of Pharmacy, Al-Zahraa University for Women, Karbala, Iraq