Iranian Journal of War and Public Health
طب جانباز
Iran J War Public Health
Medical Sciences
http://ijwph.ir
153
ijwph
2008-2622
2008-2630
10.58209/ijwph
en
jalali
1401
10
1
gregorian
2023
1
1
15
1
online
1
fulltext
en
Hepatoprotective Effects of Coenzyme Q10 against Amoxiclav-induced Hepatotoxicity in the Rat Model
آمار و اپیدمیولوژی معلولیتهای ناشی از جنگ/حادثه
Epidemiology and Statistics of War/Accident Related Injuries
پژوهشی اصيل
Original Research
<span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span cambria="" style="font-family:">Aims: </span></span></b><span style="font-size:10.0pt"><span cambria="" style="font-family:">Amoxiclav antibiotic is a commonly prescribed medication for many medical situations. One of the side effects of amoxiclav is hepatotoxicity. Coenzyme Q10, as a potent anti-oxidant, can play a beneficial role in reducing various drug-induced hepatotoxicity. The present study aimed to evaluate the hepatoprotective effects of coenzyme Q10 against amoxiclav-induced hepatotoxicity in the rat model.</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span cambria="" style="font-family:">Materials & Methods: </span></span></b><span style="font-size:10.0pt"><span cambria="" style="font-family:">24 male albino rats weighing 150-250g were randomly divided into four groups of six animals. The control group was given normal saline; the amoxiclav group was given 30mg/Kg/day of amoxiclav orally for 30 days; In the amoxiclav and CoQ10 group, each animal was given orally 30mg/Kg of amoxiclav, and 100mg/Kg CoQ10 orally daily for 30 days; In CoQ10 group, each rat was given 100mg/Kg CoQ10 orally daily for 30 days. At the end of the experiment, the animals were anesthetized and then scarified to assess the serum liver enzymes, as well as liver tissue samples were obtained for histopathological study.</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span cambria="" style="font-family:">Findings:</span></span></b><span style="font-size:10.0pt"><span cambria="" style="font-family:"> Liver function parameters were significantly elevated in the animal group treated with amoxiclav, and hepatocellular necrosis and congestion were observed in histopathological examination. Concomitant treatment with CoQ10 and amoxiclav significantly reduced the liver enzymes and improved hepatocellular congestion and inflammation.</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span cambria="" style="font-family:">Conclusion:</span></span></b><span style="font-size:10.0pt"><span cambria="" style="font-family:"> CoQ10 is a potent anti-inflammatory and anti-oxidant agent that can be used to reduce amoxiclav-induced hepatotoxicity.</span></span></span></span></span><br>
Amoxiclav,Coenzyme Q10,Liver,Toxicity,Adverse Effects,Rat,
77
82
http://ijwph.ir/browse.php?a_code=A-10-2042-1&slc_lang=en&sid=1
F.A.
Ghafil
15300319475328460024190
15300319475328460024190
No
Department of Pharmacology and Therapeutics, Faculty of Medicine, Kufa University, Kufa, Iraq
Z.
Abed al-kareem
15300319475328460024191
15300319475328460024191
No
Department of Pharmacology and Toxicology, Collage of Pharmacy, University of Kerbala, Kerbala, Iraq
S.
Abdulredha Majeed
15300319475328460024192
15300319475328460024192
No
Department of Pharmacology and Therapeutics, Faculty of Medicine, Kufa University, Kufa, Iraq
N.D.
Aziz
15300319475328460024193
15300319475328460024193
Yes
Department of Clinical Pharmacy, Collage of Pharmacy, University of Kerbala, Kerbala, Iraq
S.M.H.
Rasheed
15300319475328460024194
15300319475328460024194
No
Department of Microbiology, Faculty of Medicine, University of Kufa, Kufa, Iraq