Received: 2014/05/21 | Accepted: 2014/05/26 | Published: 2014/12/16
URL: http://ijwph.ir/article-1-409-en.html
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
2- Iranian Research Center on Aging, Social Welfare and Rehabilitation Sciences University, Tehran, Iran , reza1092@yahoo.com
3- Iranian Research Center on Aging, Social Welfare and Rehabilitation Sciences University, Tehran, Iran
4- Cell and Molecular Biology Department, Basic Sciences Faculty, University of Mazandaran, Babolsar, Iran
5- Immunoregulation Research Center, Shahed University, Tehran, Iran
6- Biostatistics Department, Statistics Faculty, Zanjan University of Medical Sciences, Zanjan, Iran
7- Institute of Biochemistry and Biophysics, Tehran University, Tehran, Iran
Aims: Aging is the result of accumulation of different detrimental changes in cells and tissues that increase the risk of disease and death with aging. Irreversible and progressive oxidative hindrance caused by “reactive oxygen species” is effective in aging. This study examined the association of age with oxidative stress indices in patients with severe pulmonary lesions by measuring the levels of these indices, 15-20 years after exposure.
Materials & Methods: This cross-sectional study was done on 289 veterans with severe pulmonary lesions and 66 identical normal subjects in 2008. Blood samples were taken in the fasting state. ELISA method was used for measuring carbonyl protein and serum total antioxidant, Thiobarbituric Acid reaction for lipid peroxidation and FOX2 for total peroxide concentration of plasma samples. Differences between groups were measured by Student-T and test using SPSS 18 software.
Findings: No significant differences were observed in levels of Carbonyl protein and oxidative stress index (the ratio of total antioxidant to total peroxide) between two patient and control groups, while total peroxide level of patient group was significantly (p<0.001) less than control group. No significant correlation was seen between age and oxidative stress indices in both groups (p>0.05).
Conclusion: In order to eliminate and control the response to mustard gas in bodies of chemical injured people, total antioxidant increases and total peroxide decreases and oxidative stress index remains unchanged.