Iranian Journal of War and Public Health

en Evaluation of Vitamin B12 in Diabetic Patients with Hypothyroidism and without Hypothyroidism سلامت جانبازان يا معلولان Veterans or Handicapped Health پژوهشی اصيل Original Research Aims: This study aimed to assess vitamin B12 levels in Iraqi participants in three groups: those with type 2 diabetes mellitus and hypothyroidism, those with type 2 diabetes mellitus without hypothyroidism, and healthy individuals. Materials & Methods: This comparative cross-sectional study included 90 participants divided into three equal groups: patients with type 2 diabetes and hypothyroidism, patients with type 2 diabetes without hypothyroidism, and healthy controls. Demographic data and blood samples were collected from all participants after obtaining informed consent. Thyroid function, glycemic status, lipid profile, renal function, and vitamin B12 levels were assessed using standardized automated analyzers. Findings: Age did not differ significantly among the groups (p=0.104), whereas participants with type 2 diabetes—particularly those with hypothyroidism—had higher body mass index, fasting blood sugar, HbA1c, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and thyroid-stimulating hormone levels and lower high-density lipoprotein cholesterol, TT3, and TT4 levels than controls. Mean vitamin B12 levels were significantly lower in participants with type 2 diabetes and hypothyroidism (202±31ng/mL) and type 2 diabetes without hypothyroidism (264±42ng/mL) than in controls (460±99ng/mL; p=0.0001). Vitamin B12 levels were inversely correlated with body mass index, Fasting blood sugar, HbA1c, total cholesterol, triglycerides, and thyroid-stimulating hormone (all p≤0.0001) but positively correlated with age (p=0.0001) and TT3 (p=0.001). Correlations between vitamin B12 and high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and TT4 were not statistically significant. Conclusion: Vitamin B12 deficiency is more prevalent among diabetic patients with hypothyroidism Diabetes Mellitus, Hypothyroidism, Lipids, Thyroid Function Test, Vitamin B12 235 240 http://ijwph.ir/browse.php?a_code=A-10-2448-1&slc_lang=en&sid=1 N.T. Tahir 15300319475328460029353 15300319475328460029353 Yes National Diabetes Center, Mustansiriyah University, Baghdad, Iraq S.A.W. ALShaban 15300319475328460029354 15300319475328460029354 No Department of Chemistry and Biochemistry, Faculty of Medicine, Mustansiriyah University, Baghdad, Iraq R.S. Akram 15300319475328460029355 15300319475328460029355 No Department of Chemistry and Biochemistry, Faculty of Medicine, Mustansiriyah University, Baghdad, Iraq D.O. Shalgam 15300319475328460029356 15300319475328460029356 No National Diabetes Center, Mustansiriyah University, Baghdad, Iraq A.W. Ammar Waham Ashor 15300319475328460029357 15300319475328460029357 No Department of Internal Medicine, Faculty of Medicine, Mustansiriyah University, Baghdad, Iraq H.D. Alrubaye 15300319475328460029358 15300319475328460029358 No Department of Internal Medicine, Faculty of Medicine, Mustansiriyah University, Baghdad, Iraq