Iranian Journal of War and Public Health
طب جانباز
Iran J War Public Health
Medical Sciences
http://ijwph.ir
153
ijwph
2008-2622
2008-2630
10.58209/ijwph
en
jalali
1401
1
1
gregorian
2022
4
1
14
2
online
1
fulltext
en
Assessment of β-catenin as a Potential Marker for Human Colorectal Carcinoma
تشخیص و درمان بیماریهای جانبازان يا معلولان
Diagnosis and Treatment of Veterans or Handicapped Diseases
پژوهشی اصيل
Original Research
<span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span cambria="" style="font-family:">Aims: </span></b><span cambria="" style="font-family:">Colorectal cancer was currently the most frequent malignant cancer of the gastrointestinal system, accounting for 13% of all malignant tumors, and it is the second most common cause of death from cancer worldwide. Aim of study was to clarify the relationship between β-catenin levels in sera, some clinical and pathological variables in Colorectal cancer patients, as well as explore the link between this biomarker and disease diagnosis and progression. </span></span></span></span><br>
<span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span cambria="" style="font-family:">Material & Methods: </span></b><span cambria="" style="font-family:">The current study included (55) Colorectal cancer patients and (35) healthy subjects. ELISA was used to calculate serum β-catenin in order to study the relationships between this biomarker and gender, age, histological type, stages, grades, tumor site, and body mass index.</span></span></span></span><br>
<span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span cambria="" style="font-family:">Findings:</span></b><span cambria="" style="font-family:"> Results showed a significant increase in the levels of β-catenin of Colorectal cancer patients in comparison with the control group (p<0.05). In parallel, no significant correlations have been found in β-catenin levels with all clinical parameters covered by the study (p>0.05). </span></span></span></span><br>
<span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span cambria="" style="font-family:">Conclusion:</span></b><span cambria="" style="font-family:"> β-catenin is a less sensitive marker for Colorectal cancer in the detection and prognosis of the advanced stages of cancer. </span></span></span></span><br>
<span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span cambria="" style="font-family:"><span style="color:red"></span></span></span></span></span><br>
β-catenin,Colorectal cancer,Serum biomarker
217
220
http://ijwph.ir/browse.php?a_code=A-10-1897-1&slc_lang=en&sid=1
Z.A.
Umran
15300319475328460024022
15300319475328460024022
No
Department of Laboratory Investigations, Faculty of Science, University of Kufa, Najaf, Iraq
A.H
Abbas Hadi
15300319475328460024023
15300319475328460024023
No
Department of Laboratory Investigations, Faculty of Science, University of Kufa, Najaf, Iraq
A.R.
Mohammad
15300319475328460024024
15300319475328460024024
Yes
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Kufa, Najaf, Iraq