Iranian Journal of War and Public Health

eISSN (English): 2980-969X
eISSN (Persian): 2008-2630
pISSN (Persian): 2008-2622
JMERC
0.3
Volume 1, Issue 3 (2009)                   Iran J War Public Health 2009, 1(3): 1-16 | Back to browse issues page

Print XML PDF HTML

History

How to cite this article
Ghazanfari T, Yaraee R, Ghasemi H, Masdari Z, Vaez Mahdavi M, Mohammad Hasan Z, et al . Relationship between Serum levels of MMP-9 and late ocular complications in. Iran J War Public Health 2009; 1 (3) :1-16
URL: http://ijwph.ir/article-1-37-en.html
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Rights and permissions
1- , tghazanfari@yahoo.com
Abstract   (21246 Views)

Background: Sulfur mustard (SM) is a chemical warfare agent which has been used
extensively during Iran- Iraq war. One of the major late complications is ocular
complications. Matrix metalloproteinases (MMPs) are a group of zinc and calciumdependent
endopeptidases which play important roles in the homeostasis of extracellular
matrix (ECM) and inflammatory conditions. It has been proved that MMP-9 , as a member
of MMPs, is involved in many inflammatory ocular disorders.
Aim: The aim of this study was to evaluate the relation between serum MMP-9 and late
ocular complications of SM exposure.
Methods: In this study, 72 chemical veterans with late ocular complications (case group)
& 63 chemical veterans without ocular complications (control group) were selected from
Sardasht via a systematic sampling. Ophthalmologic examinatia of the study group was
performed by slit lamp and serum MMP-9 was measured by ELISA sandwich method.
Results: The median of serum MMP-9 was 849.3pg/ml in the case group and 787.0pg/ml
in the control group. There was no significant statistical difference (p=0.700). There was
also no statistical relationship between serum MMP-9 and each involved ocular region.
Conclusions: In many studies, It has been proved that MMP-9 expression is increased in
tear fluid & culture media of conjunctival & corneal epithelial cells from patients with ocular
inflammatory diseases. Therefore, assessment of MMP-9 in mentioned samples of chemical
veterans with ocular complications would be valuable.

Keywords:

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author