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Volume 15, Issue 1 (2023)
Iran J War Public Health 2023, 15(1): 77-82 |
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Received: 2022/10/21 | Accepted: 2023/02/20 | Published: 2023/03/1
Received: 2022/10/21 | Accepted: 2023/02/20 | Published: 2023/03/1
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Ghafil F, Abed al-kareem Z, Abdulredha Majeed S, Aziz N, Rasheed S. Hepatoprotective Effects of Coenzyme Q10 against Amoxiclav-induced Hepatotoxicity in the Rat Model. Iran J War Public Health 2023; 15 (1) :77-82
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1- Department of Pharmacology and Therapeutics, Faculty of Medicine, Kufa University, Kufa, Iraq
2- Department of Pharmacology and Toxicology, Collage of Pharmacy, University of Kerbala, Kerbala, Iraq
3- Department of Clinical Pharmacy, Collage of Pharmacy, University of Kerbala, Kerbala, Iraq
4- Department of Microbiology, Faculty of Medicine, University of Kufa, Kufa, Iraq
2- Department of Pharmacology and Toxicology, Collage of Pharmacy, University of Kerbala, Kerbala, Iraq
3- Department of Clinical Pharmacy, Collage of Pharmacy, University of Kerbala, Kerbala, Iraq
4- Department of Microbiology, Faculty of Medicine, University of Kufa, Kufa, Iraq
Abstract (656 Views)
Aims: Amoxiclav antibiotic is a commonly prescribed medication for many medical situations. One of the side effects of amoxiclav is hepatotoxicity. Coenzyme Q10, as a potent anti-oxidant, can play a beneficial role in reducing various drug-induced hepatotoxicity. The present study aimed to evaluate the hepatoprotective effects of coenzyme Q10 against amoxiclav-induced hepatotoxicity in the rat model.
Materials & Methods: 24 male albino rats weighing 150-250g were randomly divided into four groups of six animals. The control group was given normal saline; the amoxiclav group was given 30mg/Kg/day of amoxiclav orally for 30 days; In the amoxiclav and CoQ10 group, each animal was given orally 30mg/Kg of amoxiclav, and 100mg/Kg CoQ10 orally daily for 30 days; In CoQ10 group, each rat was given 100mg/Kg CoQ10 orally daily for 30 days. At the end of the experiment, the animals were anesthetized and then scarified to assess the serum liver enzymes, as well as liver tissue samples were obtained for histopathological study.
Findings: Liver function parameters were significantly elevated in the animal group treated with amoxiclav, and hepatocellular necrosis and congestion were observed in histopathological examination. Concomitant treatment with CoQ10 and amoxiclav significantly reduced the liver enzymes and improved hepatocellular congestion and inflammation.
Conclusion: CoQ10 is a potent anti-inflammatory and anti-oxidant agent that can be used to reduce amoxiclav-induced hepatotoxicity.
Materials & Methods: 24 male albino rats weighing 150-250g were randomly divided into four groups of six animals. The control group was given normal saline; the amoxiclav group was given 30mg/Kg/day of amoxiclav orally for 30 days; In the amoxiclav and CoQ10 group, each animal was given orally 30mg/Kg of amoxiclav, and 100mg/Kg CoQ10 orally daily for 30 days; In CoQ10 group, each rat was given 100mg/Kg CoQ10 orally daily for 30 days. At the end of the experiment, the animals were anesthetized and then scarified to assess the serum liver enzymes, as well as liver tissue samples were obtained for histopathological study.
Findings: Liver function parameters were significantly elevated in the animal group treated with amoxiclav, and hepatocellular necrosis and congestion were observed in histopathological examination. Concomitant treatment with CoQ10 and amoxiclav significantly reduced the liver enzymes and improved hepatocellular congestion and inflammation.
Conclusion: CoQ10 is a potent anti-inflammatory and anti-oxidant agent that can be used to reduce amoxiclav-induced hepatotoxicity.
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