en توانبخشی جانبازان يا معلولان Rehabilitation of Veterans or Handicapped پژوهشی اصيل Original Research <span style="font-size:11pt"><span style="line-height:150%"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><span style="font-size:10.0pt"><span style="line-height:150%"><span cambria="" style="font-family:">The majority of adults worldwide suffer from musculoskeletal (MSK) disorders, which are extremely common and cause crippling pain. MSK symptoms typically appear in midlife, and there is evidence that they may be connected to the menopausal transition and the corresponding drop in estrogens. The purpose of this research is to examine how vitamin D3 insufficiency and parathyroid hormone (PTH) affect metabolic changes in menopausal women. </span></span></span>&nbsp;<span style="font-size:10.0pt"><span style="line-height:150%"><span cambria="" style="font-family:">Ninety Iraqi women diagnosed as </span></span></span><strong><span style="font-size:10.0pt"><span style="line-height:150%"><span cambria="" style="font-family:"><span style="font-weight:normal">menopause&nbsp; women&nbsp; with </span></span></span></span></strong><span style="font-size:10.0pt"><span style="background:white"><span style="line-height:150%"><span cambria="" style="font-family:"><span style="color:#1d1d1d">musculoskeletal and type 2<b> </b></span></span></span></span></span><span style="font-size:10.0pt"><span style="line-height:150%"><span cambria="" style="font-family:">&nbsp;diabetes mellitus their age range was (45-55) years.</span></span></span><strong><span style="font-size:10.0pt"><span style="line-height:150%"><span cambria="" style="font-family:"><span style="font-weight:normal"> there was shown a highly significant increase of&nbsp; HbA1C, FBS,TC and LDL between groups </span></span></span></span></strong><strong><span style="font-size:10.0pt"><span style="line-height:150%"><span cambria="" style="font-family:">(</span></span></span></strong><span style="font-size:10.0pt"><span style="line-height:150%"><span cambria="" style="font-family:">Menopause Diabetic<strong><span cambria="" style="font-family:"><span style="font-weight:normal"> women&nbsp; with </span></span></strong><span style="background:white"><span style="color:#1d1d1d">Musculoskeletal Manifestations</span></span> and control)</span></span></span><strong> </strong><strong><span style="font-size:10.0pt"><span style="line-height:150%"><span cambria="" style="font-family:"><span style="font-weight:normal">. While a highly significant decrees of HDL-C&nbsp;&nbsp;&nbsp; between groups </span></span></span></span></strong><strong><span style="font-size:10.0pt"><span style="line-height:150%"><span cambria="" style="font-family:">(</span></span></span></strong><span style="font-size:10.0pt"><span style="line-height:150%"><span cambria="" style="font-family:">Menopause Diabetic <strong><span cambria="" style="font-family:"><span style="font-weight:normal">women&nbsp; with </span></span></strong><span style="background:white"><span style="color:#1d1d1d">Musculoskeletal Manifestations</span></span><strong> </strong>and control). </span></span></span><strong><span style="font-size:10.0pt"><span style="line-height:150%"><span cambria="" style="font-family:"><span style="font-weight:normal">A highly significant increase of&nbsp; estrogen, LH, FSH,Ca and PTH&nbsp; between groups </span></span></span></span></strong><strong><span style="font-size:10.0pt"><span style="line-height:150%"><span cambria="" style="font-family:">(</span></span></span></strong><span style="font-size:10.0pt"><span style="line-height:150%"><span cambria="" style="font-family:">Menopause Diabetic<strong><span cambria="" style="font-family:"><span style="font-weight:normal"> women&nbsp; with </span></span></strong><span style="background:white"><span style="color:#1d1d1d">Musculoskeletal Manifestations</span></span> and control)</span></span></span><strong> </strong><strong><span style="font-size:10.0pt"><span style="line-height:150%"><span cambria="" style="font-family:"><span style="font-weight:normal">. While a highly significant decrees of D3&nbsp;&nbsp;&nbsp; between groups </span></span></span></span></strong><strong><span style="font-size:10.0pt"><span style="line-height:150%"><span cambria="" style="font-family:">(</span></span></span></strong><span style="font-size:10.0pt"><span style="line-height:150%"><span cambria="" style="font-family:">Menopause Diabetic <strong><span cambria="" style="font-family:"><span style="font-weight:normal">women with </span></span></strong><span style="background:white"><span style="color:#1d1d1d">Musculoskeletal Manifestations</span></span><strong> </strong>and control). &nbsp;</span></span></span><span style="font-size:10.0pt"><span style="line-height:150%"><span cambria="" style="font-family:">It can conclusion that menopausal diabetic women with hyperparathyroidism may be more susceptible to musculoskeletal symptoms because the vitamin D3&ndash;PTH&ndash;calcium axis is disrupted. Impaired bone and muscular function may be caused by vitamin D3 deficiency and raised PTH, underscoring the significance of early metabolic evaluation and treatment.</span></span></span></span></span></span></span><br> &nbsp; Estradiol , Musculoskeletal , menopause women , T2DM, Para Thyroid Hormone , Vitamin D3 0 0 http://ijwph.ir/browse.php?a_code=A-10-2481-1&slc_lang=en&sid=1 Luay asaad Mahmood No Mithal R. Alkubaisi mithalreadh@uoanbar.edu.iq Yes Noor Thair Tahir No Marwah Mohammed Nasri No Raghda Shams Akram No