Iranian Journal of War and Public Health

en Evaluation of Low-Level Laser Therapy (LLLT) on Skin Wound Healing and Inflammatory Biomarkers: A Clinical and Biophysical Study آمار و اپیدمیولوژی معلولیت‌های ناشی از جنگ/حادثه Epidemiology and Statistics of War/Accident Related Injuries توصیفی و نظرسنجی Descriptive & Survey Background: The process of healing wounds on the skin consists of various biological phenomena such as hemostasis, inflammation, proliferation, and remodeling. Nevertheless, the difficulty in healing wounds due to many factors has been the most challenging question in the clinic since persistent inflammation and the inability to regenerate tissues pose a threat to infection, make treatment lengthy, and decrease life quality.  Low-Level Laser Therapy (LLLT) also referred to as photobiomodulation, has emerged as a non-invasive procedure with the potential for enhancing tissue healing and regulating inflammation. This study investigated the impact of Low-Level Laser Therapy on the healing of wounds on the skin as well as the inflammatory biomarkers related to this process through both clinical and biophysical analysis. Methods: In this group of 360 patients with either a superficial or partial thickness skin wound, a randomized clinical trial was done. The selection of the study participants resulted in 180 patients being treated for the clinical condition, while 180 received standard care alone. For 4 weeks, participants were treated with a 660-nm diode laser (100 mW, 4 J/cm²) 3 times in a week. The following clinical parameters were evaluated: percentage of wound closure, pain intensity, rate of complete healing, patient satisfaction and the number of adverse events. The following parameters were studied in the physical assessments: local skin temperature and tissue perfusion. Biochemical makers of inflammation like CRP, TNF-alpha, and IL-6 levels were measured before and after treatment to help assess the effectiveness of the treatment given. The significance of the study results was assessed using SPSS statistics p<0.05. Results: Individuals treated with LLLT had significantly better wound closure, faster healing of the affected tissue, and better recovery from the disease compared to the group with no treatment. It was also noted that the levels of TNF-α, IL-6, and CRP tend to decrease considerably after the use of LLLT demonstrating decreased inflammation. Pain level was significantly lower and the healing and patient satisfaction rate were higher after LLLT treatment. Conclusions: Low-Level Laser Therapy remarkably improved the healing process of wounds and decreased inflammation markers in combination with conventional wound care. A combination of results from laboratory, clinical, and biophysical studies and observations support the therapeutic role of photobiomodulation in tissue regeneration and the management of inflammation. Further large multicentric studies are suggested with a longer follow up period to determine efficacy of the treatment protocols and verify the results.   Low-Level Laser Therapy, Photobiomodulation, Wound Healing, Skin Regeneration, TNF-α, Interleukin-6, C-Reactive Protein, Inflammation, Clinical Trial 1001 1013 http://ijwph.ir/browse.php?a_code=A-10-2456-2&slc_lang=en&sid=1 Bushra Ghali Yousif bushraghali2016@gmail.com 15300319475328460029326 15300319475328460029326 Yes Selma Ahmed Jassim isosalma20@gmail.com 15300319475328460029327 15300319475328460029327 No